DE BELLEFEUILLE P
Can Med Assoc J. 1963 Nov 2;89(18):933-6.
In the etiology of most congenital malformations one cannot incriminate a chromosomal aberration or a known teratogenic incident (infection or drug ingestion) during gestation. In cases of cleft lip and palate and of pyloric stenosis, the familial distribution of affected persons was shown to be explainable on the basis of partial genetic and partial environmental causation. Analysis of previously known data on the socioeconomic concomitants of severe congenital malformation showed that unsatisfactory living conditions are present in approximately one-half of the cases; it is suggested that the most fruitful approach to prevention lies in the direction of public hygiene.
在大多数先天性畸形的病因中,无法归咎于染色体畸变或孕期已知的致畸事件(感染或药物摄入)。在唇腭裂和幽门狭窄的病例中,受影响人群的家族分布显示,部分可基于遗传因素、部分可基于环境因素来解释。对先前已知的严重先天性畸形社会经济相关因素数据的分析表明,约一半的病例存在生活条件不佳的情况;有人认为,最有效的预防方法在于公共卫生领域。