Altunhan Hüseyin, Annagür Ali, Konak Murat, Ertuğrul Sabahattin, Ors Rahmi, Koç Hasan
Division of Neonatology, Selcuk University Meram Medical Faculty, Konya, Turkey.
Br J Oral Maxillofac Surg. 2012 Sep;50(6):541-4. doi: 10.1016/j.bjoms.2011.08.001. Epub 2011 Aug 30.
Additional congenital anomalies have often been found in patients with orofacial clefts. We wanted to find out the incidence and type of congenital malformations that may accompany cleft palate (CP) and cleft lip and palate (CLP) in babies born in the Konya region. A total of 121 newborn babies with CP or CLP were prospectively included in the study, and all were assessed in detail for congenital anomalies. Of 121 babies, 86 (71%) had CLP and 35 (29%) had CP. There was at least one congenital malformation in 80 (66%) of the cases. Additional congenital malformations were seen in 26 (74%) of the 35 with isolated CP, and 54 (63%) in the 86 patients with CLP (p<0.05). The most common congenital malformation was congenital heart disease, followed by head and neck anomalies. The most common congenital heart disease was atrial septal defect. A serious chromosomal anomaly was found in 18/121 patients with CP or CLP (15%). Of the 80 babies in whom congenital malformations were found, 31 (39%) had dysmorphic features. While 21 (68%) of dysmorphic cases had isolated CP, 10 (32%) had CLP (p<0.05). The rates of premature delivery, intrauterine growth retardation, and consanguinity between parents were higher in patients with CP or CLP. The neonatal mortality was 20% (n=24). Our results indicate that at least one congenital anomaly is also present in about two-thirds of newborn babies with CP and CLP, and these anomalies significantly increase their morbidity and mortality. All newborn babies with CP and CLP should be screened for additional congenital anomalies, particularly of the cardiovascular system.
口面部裂隙患者常伴有其他先天性异常。我们想了解科尼亚地区出生的患有腭裂（CP）和唇腭裂（CLP）的婴儿中可能伴随的先天性畸形的发生率和类型。共有121例患有CP或CLP的新生儿被前瞻性纳入研究，并对所有患儿的先天性异常进行了详细评估。121例婴儿中，86例（71%）患有CLP，35例（29%）患有CP。80例（66%）病例至少存在一种先天性畸形。35例孤立性CP患者中有26例（74%）出现其他先天性畸形，86例CLP患者中有54例（63%）出现其他先天性畸形（p<0.05）。最常见的先天性畸形是先天性心脏病，其次是头颈部异常。最常见的先天性心脏病是房间隔缺损。121例CP或CLP患者中有18例（15%）发现严重染色体异常。在发现先天性畸形的80例婴儿中，31例（39%）有畸形特征。畸形病例中，21例（68%）为孤立性CP，10例（32%）为CLP（p<0.05）。CP或CLP患者的早产、宫内生长迟缓及父母近亲结婚率较高。新生儿死亡率为20%（n = 24）。我们的结果表明，约三分之二的患有CP和CLP的新生儿至少还存在一种先天性异常，这些异常显著增加了他们的发病率和死亡率。所有患有CP和CLP的新生儿都应筛查是否存在其他先天性异常，尤其是心血管系统异常。
