Schweinsberg F, Schott-Kollat P, Bürkle G
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):231-6. doi: 10.1007/BF00305361.
Substitution with a methyl group in the 2-, 3- or 4-position respectively of the phenyl moiety of N-methyl-N-nitrosobenzylamine results in a considerable reduction of the acute toxicity. (LD 50 of MNBA: 18 mg/kg (Druckrey et al., 1967), 2-Me-MNBA: 90 mg/kg, 3-Me-MNBA: 600 mg/kg, 4-Me-MNBA: 400 mg/kg). However, the introduction of the methyl group influences the carcinogenic activity of MNBA in rats and its organotropy, only to a small extent. Long-term administration of 5 and 15 ppm respectively of the isomeric N-nitroso compounds in the drinking water produces in all animals carcinomas of the oesophagus and the pharynx.
在N-甲基-N-亚硝基苄胺的苯基部分的2-、3-或4-位分别用甲基取代，会使急性毒性显著降低。（甲基亚硝基苄胺的半数致死量：18毫克/千克（德鲁克里等人，1967年），2-甲基-N-亚硝基苄胺：90毫克/千克，3-甲基-N-亚硝基苄胺：600毫克/千克，4-甲基-N-亚硝基苄胺：400毫克/千克）。然而，甲基的引入对大鼠体内甲基亚硝基苄胺的致癌活性及其器官亲和性的影响很小。在饮用水中分别长期给予5 ppm和15 ppm的同分异构N-亚硝基化合物，会使所有动物发生食道癌和咽癌。
