三碘甲状腺原氨酸对大鼠心脏腺嘌呤核苷酸和蛋白质生物合成的影响。

Effect of triiodothyronine on the biosynthesis of adenine nucleotides and proteins in the rat heart.

Zimmer H G, Steinkopff G, Gerlach E

Adv Exp Med Biol. 1977;76A:50-8. doi: 10.1007/978-1-4613-4223-6_6.

Abstract

During the development of myocardial hypertrophy induced by 3,3',5-triiodo-L-thyronine the enhancement of de novo synthesis of adenine nucleotides occurs very early and precedes the increase of protein synthesis. In this respect there is a striking parallelism with other types of cardiac hypertrophy. 2) The acceleration of adenine nucleotide synthesis under these experimental conditions seems to be due to a greater availability of cardiac 5-phosphoribosyl-1-pyrophosphate. 3) The triiodothyronine-induced enhancement of adenine nucleotide synthesis can be attenuated by beta-receptor-blocking agents.

摘要

在由3,3',5-三碘-L-甲状腺原氨酸诱导的心肌肥大发展过程中，腺嘌呤核苷酸从头合成的增强很早就出现了，且先于蛋白质合成的增加。在这方面，与其他类型的心脏肥大有显著的平行关系。2) 在这些实验条件下，腺嘌呤核苷酸合成的加速似乎是由于心脏5-磷酸核糖-1-焦磷酸的可用性增加。3) β受体阻滞剂可减弱三碘甲状腺原氨酸诱导的腺嘌呤核苷酸合成增强。