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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zimmer H G, Steinkopff G, Gerlach E

Adv Exp Med Biol. 1977;76A:50-8. doi: 10.1007/978-1-4613-4223-6_6.

During the development of myocardial hypertrophy induced by 3,3',5-triiodo-L-thyronine the enhancement of de novo synthesis of adenine nucleotides occurs very early and precedes the increase of protein synthesis. In this respect there is a striking parallelism with other types of cardiac hypertrophy. 2) The acceleration of adenine nucleotide synthesis under these experimental conditions seems to be due to a greater availability of cardiac 5-phosphoribosyl-1-pyrophosphate. 3) The triiodothyronine-induced enhancement of adenine nucleotide synthesis can be attenuated by beta-receptor-blocking agents.

在由3,3',5-三碘-L-甲状腺原氨酸诱导的心肌肥大发展过程中，腺嘌呤核苷酸从头合成的增强很早就出现了，且先于蛋白质合成的增加。在这方面，与其他类型的心脏肥大有显著的平行关系。2) 在这些实验条件下，腺嘌呤核苷酸合成的加速似乎是由于心脏5-磷酸核糖-1-焦磷酸的可用性增加。3) β受体阻滞剂可减弱三碘甲状腺原氨酸诱导的腺嘌呤核苷酸合成增强。

Zimmer H G, Steinkopff G, Gerlach E

Adv Exp Med Biol. 1977;76A:50-8. doi: 10.1007/978-1-4613-4223-6_6.

During the development of myocardial hypertrophy induced by 3,3',5-triiodo-L-thyronine the enhancement of de novo synthesis of adenine nucleotides occurs very early and precedes the increase of protein synthesis. In this respect there is a striking parallelism with other types of cardiac hypertrophy. 2) The acceleration of adenine nucleotide synthesis under these experimental conditions seems to be due to a greater availability of cardiac 5-phosphoribosyl-1-pyrophosphate. 3) The triiodothyronine-induced enhancement of adenine nucleotide synthesis can be attenuated by beta-receptor-blocking agents.

在由3,3',5-三碘-L-甲状腺原氨酸诱导的心肌肥大发展过程中，腺嘌呤核苷酸从头合成的增强很早就出现了，且先于蛋白质合成的增加。在这方面，与其他类型的心脏肥大有显著的平行关系。2) 在这些实验条件下，腺嘌呤核苷酸合成的加速似乎是由于心脏5-磷酸核糖-1-焦磷酸的可用性增加。3) β受体阻滞剂可减弱三碘甲状腺原氨酸诱导的腺嘌呤核苷酸合成增强。