Lin J J, Sancar A
Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill 27599.
Mol Microbiol. 1992 Aug;6(16):2219-24. doi: 10.1111/j.1365-2958.1992.tb01398.x.
Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.
核苷酸切除修复是去除DNA损伤的主要途径。（A）BC核酸外切酶是在大肠杆菌中启动核苷酸切除修复的核酸酶活性。在本综述中，我们聚焦于对该酶结构功能以及修复途径反应机制的当前理解。此外，还总结了近期关于大肠杆菌中活跃转录基因优先修复的生化研究。
