• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠的长期隔离应激

LONG-TERM ISOLATION STRESS IN RATS.

作者信息

WIBERG G S, GRICE H C

出版信息

Science. 1963 Oct 25;142(3591):507. doi: 10.1126/science.142.3591.507.

DOI:10.1126/science.142.3591.507
PMID:14064449
Abstract

Rats isolated for long periods became nervous and aggressive and developed caudal dermatitis ( scaly tail). After 13 weeks of isolation, rats had heavier adrenals and thyroid and lighter spleen and thymus compared with rats kept in community cages. This indicates an endocrinopathy with hyperfunction of the adrenal cortex.

摘要

长期隔离的大鼠变得紧张、好斗，并出现尾部皮炎（尾巴鳞片化）。与饲养在群居笼中的大鼠相比，隔离13周后的大鼠肾上腺和甲状腺更重，脾脏和胸腺更轻。这表明存在肾上腺皮质功能亢进的内分泌病。

相似文献

1
LONG-TERM ISOLATION STRESS IN RATS.大鼠的长期隔离应激
Science. 1963 Oct 25;142(3591):507. doi: 10.1126/science.142.3591.507.
2
[THE INFLUENCE OF ADRENAL CORTEX INSUFFICIENCY AND HYPERFUCTION ON THE SENSITIVITY OF RATS AND MICE TO CARBON MOXOIDE POISONING].[肾上腺皮质功能不全与功能亢进对大鼠和小鼠一氧化碳中毒敏感性的影响]
Farmakol Toksikol. 1964 May-Jun;27:343-5.
3
ELECTRICAL STIMULATION OF THE HYPOTHALAMUS: SIMULTANEOUS EFFECTS ON THE PITUITARY-ADRENAL AND THYROID SYSTEMS OF THE RAT.下丘脑的电刺激：对大鼠垂体-肾上腺和甲状腺系统的同时影响。
Endocrinology. 1964 Sep;75:417-27. doi: 10.1210/endo-75-3-417.
4
[Effect of testenate on the morphology of the adrenal cortex under conditions of combined stress].[睾酮庚酸酯在复合应激条件下对肾上腺皮质形态的影响]
Probl Endokrinol (Mosk). 1974 Nov-Dec;20(6):64-7.
5
[Thyroid function in adrenal cortex hyperfunction syndrome; its changes after hormonal and surgical treatment].肾上腺皮质功能亢进综合征中的甲状腺功能；激素及手术治疗后的变化
Prog Med (Napoli). 1956 Feb 15;12(3):70-3.
6
EFFECT OF STRESS FROM HIGH PROTEIN DIETS ON VITAMIN A METABOLISM IN CHICKS.高蛋白饮食压力对雏鸡维生素A代谢的影响。
J Nutr. 1964 Feb;82(2):188-96. doi: 10.1093/jn/82.2.188.
7
RESPONSE OF A SERUM GLYCOPROTEIN TO TISSUE INJURY AND NECROSIS. II. THE ROLE OF THE LIVER, ADRENAL GLAND AND OTHER ORGANS.一种血清糖蛋白对组织损伤和坏死的反应。II. 肝脏、肾上腺及其他器官的作用。
Br J Exp Pathol. 1965 Apr;46(2):155-63.
8
[INTERACTION OF THE ADRENAL CORTEX AND THYROID GLAND IN NORMAL CONDITIONS AND IN CONDITIONS OF COLD STRESS].[正常状态及冷应激状态下肾上腺皮质与甲状腺的相互作用]
Biull Eksp Biol Med. 1964 Feb;57:45-7.
9
[FUNCTIONAL STATUS OF THE ADRENAL CORTEX IN FUNCTIONAL DISORDERS OF THE THYROID GLAND UNDER EXPERIMENTAL AND CLINICAL CONDITIONS. (REVIEW OF THE LITERATURE)].[实验和临床条件下甲状腺功能紊乱时肾上腺皮质的功能状态。（文献综述）]
Probl Endokrinol Gormonoter. 1964 May-Jun;10:118-24.
10
Studies in patients with adrenocortical hyperfunction. III. IN vitro secretion of steroids by human adrenal glands.肾上腺皮质功能亢进患者的研究。III. 人肾上腺类固醇的体外分泌
J Clin Endocrinol Metab. 1960 May;20:765-79. doi: 10.1210/jcem-20-5-765.

引用本文的文献

1
Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner.短期社会隔离作用于下丘脑神经元，以性别和环境依赖的方式促进社会行为。
Elife. 2025 Mar 4;13:RP94924. doi: 10.7554/eLife.94924.
2
Effects of short-term isolation on social behaviors in prairie voles.短期隔离对草原田鼠社会行为的影响。
PLoS One. 2024 Nov 11;19(11):e0313172. doi: 10.1371/journal.pone.0313172. eCollection 2024.
3
Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence.
前额叶小白蛋白中间神经元的失调会导致青春期社会隔离应激诱导的成年期攻击行为。
Front Mol Neurosci. 2022 Oct 4;15:1010152. doi: 10.3389/fnmol.2022.1010152. eCollection 2022.
4
Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.急性隔离对小鼠发声和非发声社交行为的性别和情境依赖性影响。
PLoS One. 2021 Sep 1;16(9):e0255640. doi: 10.1371/journal.pone.0255640. eCollection 2021.
5
Evaluation of Treatment Options for Ulcerative Dermatitis in the P Rat.评价 P 鼠溃疡性皮肤病的治疗方案。
J Am Assoc Lab Anim Sci. 2021 May 1;60(3):311-318. doi: 10.30802/AALAS-JAALAS-20-000058. Epub 2021 May 3.
6
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation.社交稳态的神经回路：急性与慢性社交隔离的后果。
Cell. 2021 Mar 18;184(6):1500-1516. doi: 10.1016/j.cell.2021.02.028. Epub 2021 Mar 9.
7
Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats.青少年雄性达尔盐敏感大鼠 1 个月隔离的行为、代谢和肾脏结局。
Am J Physiol Regul Integr Comp Physiol. 2020 Dec 1;319(6):R684-R689. doi: 10.1152/ajpregu.00236.2020. Epub 2020 Oct 14.
8
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.神经肽 Tac2 控制慢性社会隔离应激诱导的分布式脑状态。
Cell. 2018 May 17;173(5):1265-1279.e19. doi: 10.1016/j.cell.2018.03.037.
9
The Evidence for Altered BDNF Expression in the Brain of Rats Reared or Housed in Social Isolation: A Systematic Review.饲养或饲养在社会隔离环境中的大鼠大脑中脑源性神经营养因子（BDNF）表达改变的证据：一项系统综述。
Front Behav Neurosci. 2017 May 31;11:101. doi: 10.3389/fnbeh.2017.00101. eCollection 2017.
10
Post-traumatic stress disorder and beyond: an overview of rodent stress models.创伤后应激障碍及其他：啮齿动物应激模型概述。
J Cell Mol Med. 2017 Oct;21(10):2248-2256. doi: 10.1111/jcmm.13161. Epub 2017 Apr 4.