Ansaldi N, Dell'Olio D, Tavassoli K, Bonzano L, Guaraglia L, Norelli M T, Quazza G, Guala A, Zannino L, Bracone A
Instito Discipline Pediatriche, Università di Torino.
Minerva Pediatr. 1992 Jul-Aug;44(7-8):371-6.
The incidence of coeliac disease (CD) was calculated on 304 patients under eighteen who were born in the city of Turin and its province in the years 1975-1989; the prevalence on 494 patients who live in the Piedmont Region. The mean crude yearly incidence was 0.511/1000 (1:1957 live birth). It varied from year to year, reaching minimum values in the years 1984-1987. In a contemporary epidemiological study, the mean crude incidence of CD in Italy was 1.2/1000 (1:833 live birth) twice the rate observed in Turin. The prevalence of paediatric CD in Piedmont was 113 per million inhabitants. Since CD has a normal life expectancy, its prevalence may be expected to increase. In the provinces of Novara, Alessandria and Asti CD prevalence was lower than in the others. Mean age at onset was 6 mos in 1975 and increased to 34 mos in 1989. Mean age at diagnosis was 15 mos in 1981, and 7 yrs in 1989. Symptoms were more numerous and severe in patients under 12 mos of age, and became fewer and often atypical in older children. We can therefore speculate that the trend towards a decreasing incidence of CD in recent years my be due to delayed diagnosis.
对1975年至1989年出生在都灵市及其省份的304名18岁以下患者计算了乳糜泻（CD）的发病率；对居住在皮埃蒙特地区的494名患者计算了患病率。年平均粗发病率为0.511/1000（1:1957活产）。发病率逐年变化，在1984年至1987年达到最低值。在一项当代流行病学研究中，意大利CD的年平均粗发病率为1.2/1000（1:833活产），是都灵观察到的发病率的两倍。皮埃蒙特地区儿童CD的患病率为每百万居民113例。由于CD患者的预期寿命正常，其患病率可能会上升。在诺瓦拉、亚历山德里亚和阿斯蒂省，CD患病率低于其他地区。1975年发病的平均年龄为6个月，到1989年增至34个月。1981年诊断时的平均年龄为15个月，1989年为7岁。12个月以下患者的症状更多、更严重，年龄较大的儿童症状较少且往往不典型。因此，我们可以推测，近年来CD发病率下降的趋势可能是由于诊断延迟所致。
