Antoni H
Basic Res Cardiol. 1977 Mar-Jun;72(2-3):140-6. doi: 10.1007/BF01906352.
Excitation-contraction coupling of the mammalian myocardium is widely assumed to comprise the following chain of events: (1) Influx of Ca++ into the cell during the plateau phase of the action potential as well as Ca++ release from the subsarcolemmal cisternae of sarcoplasmic reticulum. (2) Activation of the contractile proteins by interaction of Ca++ with the troponin-tropomyosin system. (3) Relaxation due to reuptake of Ca++ by the sarcotubular system as well as by pumping of Ca++ out of the cell through the surface membrane and the transverse tubular system. (4) Movement of Ca++ in the longitudinal tubules back to the subsarcolemmal cisternae. A short comment is included about the effects of hypertrophy on the excitatory processes as well as on cellular structural constituents directly involved in excitation-contraction coupling.
哺乳动物心肌的兴奋 - 收缩偶联通常被认为包括以下一系列事件：(1) 在动作电位的平台期，Ca++流入细胞以及从肌浆网的肌膜下池释放Ca++。(2) Ca++与肌钙蛋白 - 原肌球蛋白系统相互作用激活收缩蛋白。(3) 由于肌管系统重新摄取Ca++以及通过表面膜和横管系统将Ca++泵出细胞而导致舒张。(4) Ca++在纵管中移动回到肌膜下池。文中还简要评论了肥大对兴奋过程以及对直接参与兴奋 - 收缩偶联的细胞结构成分的影响。
