Protsenko O A, Filippov A A, Kutyrev V V
Mol Gen Mikrobiol Virusol. 1992 Mar-Apr(3-4):20-4.
Yersinia pestis strains with the typical plasmid patterns were shown to have the heterogenic populations. Heterogeneity is increased by cultivation passages in artificial nutrient media and is manifested in plasmid elimination within several clones, plasmid integration into the chromosome, appearance of auxiliary plasmids or the ones with increased molecular masses. Passages of strains in experimental animals result in populations homogeneity with the typical plasmid patterns within all clones tested. The clones having changed the plasmid content and selected from heterogenic populations pertain their properties when cultivated in nutrient media and passaged in experimental animals.
具有典型质粒图谱的鼠疫耶尔森菌菌株显示出具有异质群体。在人工营养培养基中传代培养会增加异质性，表现为几个克隆内质粒的消除、质粒整合到染色体中、辅助质粒或分子量增加的质粒的出现。菌株在实验动物中的传代导致所有测试克隆内具有典型质粒图谱的群体同质化。从异质群体中选择的改变了质粒含量的克隆在营养培养基中培养并在实验动物中传代时保留其特性。
