Heiss H W, Wink K, Barmeyer J, Keul J, Reindell H
Basic Res Cardiol. 1977 Mar-Jun;72(2-3):293-8. doi: 10.1007/BF01906376.
It is shown in trained and untrained healthy individuals that the energy requirement of the physiologically hypertrophied heart is lower at rest and even more pronounced during submaximal heavy exercise compared to the non-hypertrophied state. This difference exceeds the changes which could have been anticipated by deviations in hemodynamics and total heart weight. In patients with mild or moderate aortic insufficiency the energy expenditure of the pathologically hypertrophied heart per unit tissue mass is comparable to the non-hypertrophied state at rest or during exercise. It is increased in severe aortic regurgitation or additional myocarditis. The transition from compensation to failure may be associated with a steep decreased of the metabolic and flow reserve of the whole heart.
在受过训练和未受过训练的健康个体中均显示，与非肥厚状态相比，生理性肥厚心脏在静息时的能量需求较低，在次最大强度的剧烈运动期间更为明显。这种差异超过了血流动力学和全心重量偏差所预期的变化。在轻度或中度主动脉瓣关闭不全的患者中，病理性肥厚心脏每单位组织质量的能量消耗在静息或运动时与非肥厚状态相当。在严重主动脉瓣反流或合并心肌炎时能量消耗增加。从代偿到失代偿的转变可能与全心代谢和血流储备的急剧下降有关。
