• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE.

作者信息

BIRNIE G D, KROEGER H, HEIDELBERGER C

出版信息

Biochemistry. 1963 May-Jun;2:566-72. doi: 10.1021/bi00903a031.

DOI:10.1021/bi00903a031
PMID:14069549
Abstract
摘要

相似文献

1
STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE.氟化嘧啶的研究。十八。核苷磷酸化酶对5-氟-2'-脱氧尿苷及相关化合物的降解
Biochemistry. 1963 May-Jun;2:566-72. doi: 10.1021/bi00903a031.
2
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.氟化嘧啶。XX。5-三氟甲基-2'-脱氧尿苷对5-氟-2'-脱氧尿苷核苷磷酸化酶裂解的抑制作用。
Biochim Biophys Acta. 1963 Oct 15;76:315-8.
3
FLUORINATED PYRIMIDINES. 23. FURTHER STUDIES ON NUCLEOSIDE PHOSPHORYLASE.
Biochim Biophys Acta. 1964 Dec 16;91:639-41. doi: 10.1016/0926-6550(64)90013-1.
4
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
Biochim Biophys Acta. 1964 Dec 16;91:636-8. doi: 10.1016/0926-6550(64)90012-x.
5
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.氟化嘧啶。XXV. 嘧啶类似物对艾氏腹水癌细胞胸苷酸合成酶的抑制作用。
Biochim Biophys Acta. 1965 May 11;103:177-9.
6
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.嘧啶核苷磷酸化酶的特异性及5-氟-2'-脱氧尿苷的磷酸解作用
Cancer Res. 1980 Mar;40(3):507-11.
7
SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES.小鼠尿苷磷酸化酶的特异性。色谱分析、纯化及性质
J Biol Chem. 1964 Mar;239:805-12.
8
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.氟化嘧啶。二十九。2'，3'-脱氢-5-氟-2'-脱氧尿苷和2'，3'-二脱氧-5-氟尿苷的合成。
J Med Chem. 1967 Nov;10(6):1066-70. doi: 10.1021/jm00318a017.
9
Fluorinated pyrimidines. 34. Structure-activity studies of methylated 5-fluoro-2'-deoxyuridine derivatives.氟化嘧啶。34. 甲基化5-氟-2'-脱氧尿苷衍生物的构效关系研究。
J Med Chem. 1970 Jan;13(1):70-3. doi: 10.1021/jm00295a018.
10
DEOXYRIBOSYL TRANSFER. I. THYMIDINE PHOSPHORYLASE AND NUCLEOSIDE DEOXYRIBOSYLTRANSFERASE IN NORMAL AND MALIGNANT TISSUES.脱氧核糖基转移。I. 正常组织和恶性组织中的胸苷磷酸化酶和核苷脱氧核糖基转移酶
J Biol Chem. 1964 Aug;239:2618-21.

引用本文的文献

1
and Fluorouracil-Based Chemotherapy: Mini Review and Case Report.以及基于氟尿嘧啶的化疗：综述与病例报告
Pharmaceutics. 2019 May 1;11(5):199. doi: 10.3390/pharmaceutics11050199.
2
Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine.肿瘤靶向口服抗癌前药的潜在发展：吉西他滨的氨基酸和二肽单酯前药。
Molecules. 2017 Aug 10;22(8):1322. doi: 10.3390/molecules22081322.
3
Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver.氟尿苷胆汁酸前药的合成及其靶向肝脏的体外评价
Int J Pharm. 2014 Nov 20;475(1-2):597-604. doi: 10.1016/j.ijpharm.2014.09.014. Epub 2014 Sep 16.
4
The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs.氟尿苷和吉西他滨的二肽单酯前药 - 口服可给予的核苷类似物的可行性。
Pharmaceuticals (Basel). 2014 Jan 27;7(2):169-91. doi: 10.3390/ph7020169.
5
The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability.具有D-对映体氨基酸的口服可给药吉西他滨前药的开发：增强膜通透性和酶稳定性。
Eur J Pharm Biopharm. 2014 Apr;86(3):514-23. doi: 10.1016/j.ejpb.2013.12.009. Epub 2013 Dec 19.
6
Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells.卡波西肉瘤相关疱疹病毒编码的ORFK13/vFLIP在内皮细胞中诱导的基因调控和功能改变。
J Virol. 2009 Mar;83(5):2140-53. doi: 10.1128/JVI.01871-08. Epub 2008 Dec 17.
7
Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.通过靶向hPEPT1转运蛋白，氟尿苷氨基酸单酯前药增强吸收并抑制生长。
Molecules. 2008 Jun 28;13(7):1441-54. doi: 10.3390/molecules13071441.
8
Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.氟尿苷二肽前药增强癌细胞生长抑制作用：转运体亲和力和代谢稳定性增加。
Mol Pharm. 2008 Sep-Oct;5(5):717-27. doi: 10.1021/mp800008c. Epub 2008 Jul 25.
9
A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients.胸苷磷酸化酶表达及5-氟尿嘧啶在口咽癌患者中增加敏感性的可能作用。
J Cell Mol Med. 2007 Mar-Apr;11(2):362-8. doi: 10.1111/j.1582-4934.2007.00007.x. Epub 2007 Mar 22.
10
Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.氟尿苷氨基酸酯前药：增强Caco-2细胞通透性及对糖苷键代谢的抗性
Pharm Res. 2005 Sep;22(9):1510-8. doi: 10.1007/s11095-005-6156-9. Epub 2005 Aug 24.