Foster J W, Brennan F E, Hampikian G K, Goodfellow P N, Sinclair A H, Lovell-Badge R, Selwood L, Renfree M B, Cooper D W, Graves J A
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
Nature. 1992 Oct 8;359(6395):531-3. doi: 10.1038/359531a0.
In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome.
在哺乳动物中，睾丸决定受Y染色体所携带的睾丸决定因子的控制。SRY是从人类Y染色体的性别决定区域克隆出来的一个基因，在人类和小鼠中它被认为等同于睾丸决定因子。我们利用人类SRY探针从两种有袋类动物的Y染色体中鉴定并克隆相关基因。真兽亚纲和后兽亚纲位于Y染色体上的SRY序列比较表明，这些基因进化迅速，尤其是在编码DNA结合HMG框的区域之外。SRY同源物，与小鼠Ube1y同源物一起，是在有袋类动物Y染色体上首次被鉴定出来的基因。
