PARISH W E, HALL L W, COOMBS R R
Immunology. 1963 Sep;6(5):462-71.
The effect of several anaesthetics on anaphylaxis was tested on guinea-pigs sensitized to milk and challenged by intravenous injection or inhalation. No protection from fatal anaphylaxis was conferred by halothane, diethyl ether volatilized by air, nitrous oxide and trichloroethylene with oxygen, or pentobarbitone sodium when the animals were challenged by intravenous injection, and death was demonstrated to be due to asphyxia following bronchial constriction. However, a mixture of carbon dioxide and oxygen protected the sensitized animals from the immediate fatal effects of intravenous challenge but it did not suppress all signs of anaphylaxis. Diethyl ether volatilized by air or oxygen provided some protection from challenge by inhalation, but none was provided by halothane or pentobarbitone sodium. Anaphylaxis may be modified but its fatal outcome not prevented by the majority of the anaesthetics used. It is considered that individuals specifically sensitized to some article of their diet may die of anaphylaxis following inhalation of vomit containing the antigen when they are deeply asleep or anaesthetized.
在对牛奶致敏并通过静脉注射或吸入进行激发的豚鼠身上测试了几种麻醉剂对过敏反应的影响。当动物通过静脉注射进行激发时，氟烷、空气挥发的乙醚、一氧化二氮和氧气混合的三氯乙烯或戊巴比妥钠均未对致命性过敏反应起到保护作用，并且已证明死亡是由于支气管收缩后的窒息所致。然而，二氧化碳和氧气的混合物可保护致敏动物免受静脉注射激发的即刻致命影响，但并未抑制过敏反应的所有体征。空气或氧气挥发的乙醚对吸入激发提供了一定保护，但氟烷或戊巴比妥钠则没有。大多数使用的麻醉剂可能会改变过敏反应，但无法防止其致命后果。据认为，对某些饮食成分具有特异性致敏的个体在深度睡眠或麻醉时吸入含有抗原的呕吐物后可能死于过敏反应。
