甲醛对微生物的作用。III. 亚致死浓度甲醛对产气气杆菌的杀菌作用
ACTION OF FORMALDEHYDE ON MICROORGANISMS. III. BACTERICIDAL ACTION OF SUBLETHAL CONCENTRATIONS OF FORMALDEHYDE ON AEROBACTER AEROGENES.
作者信息
NEELY W B
出版信息
J Bacteriol. 1963 Sep;86(3):445-8. doi: 10.1128/jb.86.3.445-448.1963.
Neely, W. Brock (The Dow Chemical Co., Midland, Mich.). Action of formaldehyde on microorganisms. III. Bactericidal action of sublethal concentrations of formaldehyde on Aerobacter aerogenes. J. Bacteriol. 86:445-448. 1963.-Bacteriostatic concentrations of formaldehyde were found to be bactericidal during the initial growth period. This bactericidal activity was due to the primary induction of unbalanced growth by formaldehyde. The subsequent formation of 1,3-thiazane-4-carboxylic acid prevented the synthesis of methionine. This dual activity of formaldehyde resulted in an inhibition of both nuclear and cytoplasmic syntheses, and created the normal bacteriostatic condition that has been observed before with sublethal concentrations of formaldehyde.
尼利，W. 布罗克（陶氏化学公司，密歇根州米德兰）。甲醛对微生物的作用。III. 亚致死浓度甲醛对产气气杆菌的杀菌作用。《细菌学杂志》86:445 - 448。1963年。研究发现，甲醛的抑菌浓度在细菌生长初期具有杀菌作用。这种杀菌活性是由于甲醛最初诱导了生长失衡。随后形成的1,3 - 噻嗪烷 - 4 - 羧酸阻止了蛋氨酸的合成。甲醛的这种双重活性导致了细胞核和细胞质合成的抑制，并产生了之前在亚致死浓度甲醛作用下所观察到的正常抑菌状态。
Zotero 插件