Haupt M, Kurz A, Pollmann S, Romero B
Psychiatrische Klinik, Technischen Universität München.
Nervenarzt. 1992 Sep;63(9):561-5.
Since the first description of Alzheimer's disease rapid symptom progression and relatively severe cognitive symptoms have been frequently associated with early onset age, while slow symptom progression and relatively mild cognitive symptoms were often related to late onset age. In a longitudinal study of 90 patients with mild to moderate Alzheimer's disease we investigated these hypotheses. We found that neither severity of cognitive symptoms nor symptom progression in Alzheimer's disease were associated with onset age. In addition, a comparison of extreme groups (group 1: less than 60 years of age; group 2: greater than 75 years of age), taken from the study sample, showed similar results with respect to the independent variables. The results of this study suggest that the interindividual variability of cognitive impairment as well as the large variation of symptom progression in Alzheimer's disease cannot be explained by onset age.
自从首次描述阿尔茨海默病以来，快速的症状进展和相对严重的认知症状常常与早发年龄相关，而缓慢的症状进展和相对较轻的认知症状则通常与晚发年龄有关。在一项对90例轻度至中度阿尔茨海默病患者的纵向研究中，我们对这些假设进行了调查。我们发现，阿尔茨海默病的认知症状严重程度和症状进展均与发病年龄无关。此外，从研究样本中选取极端组（第1组：年龄小于60岁；第2组：年龄大于75岁）进行比较，结果显示自变量方面的结果相似。这项研究的结果表明，阿尔茨海默病中认知障碍的个体间差异以及症状进展的巨大差异无法用发病年龄来解释。
