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[血清素对大鼠中脑突触体无细胞制剂水平上谷氨酸脱羧酶和γ-氨基丁酸转氨酶酶活性的体外作用]

[In vitro effect of serotonin on the enzyme activities of glutamate decarbosylase and GABA transaminase at the level of acellular preparations of rat mesencephalon synaptosomes].

作者信息

Belin M F, Kouyoumdjian J C, Gonnard P, Jouvet M

出版信息

C R Seances Soc Biol Fil. 1976;170(6):1243-7.

PMID:140743
Abstract

The effect of serotonin on glutamate decarboxylase and GABA-transaminase was studied, in vitro, in synaptosome homogenates from rat mesencephalon. Serotonin dissolved in the incubation medium inhibits glutamate decarboxylase activity and stimulates GABA-transaminase activity.

摘要

在体外对来自大鼠中脑的突触体匀浆进行研究，观察血清素对谷氨酸脱羧酶和γ-氨基丁酸转氨酶的作用。溶解于孵育培养基中的血清素会抑制谷氨酸脱羧酶的活性，并刺激γ-氨基丁酸转氨酶的活性。

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