Wada Y, Hasegawa H, Nakamura M, Yamaguchi N
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Neurosci Lett. 1992 Apr 13;138(1):115-8. doi: 10.1016/0304-3940(92)90485-p.
The effects of a serotonin (5-HT) receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), on epileptic photosensitivity were studied in the lateral geniculate-kindled cat. 5-MeODMT at 4 mg/kg significantly suppressed photically induced myoclonus, but not paroxysmal EEG activity, at 0.5-1 h after injection. This antiepileptic effect was seen in association with the appearance of behavioral signs similar to those seen in the 5-HT syndrome. The present data provide further evidence that 5-HT plays an important role in photosensitive epilepsy, and suggest that the inhibitory effect of 5-MeODMT on photosensitivity results from its agonist action at 5-HT1 receptors.
在外侧膝状体点燃猫模型中研究了血清素（5-羟色胺，5-HT）受体激动剂5-甲氧基-N，N-二甲基色胺（5-MeODMT）对癫痫光敏性的影响。注射后0.5 - 1小时，4mg/kg的5-MeODMT可显著抑制光诱导的肌阵挛，但不能抑制阵发性脑电图活动。这种抗癫痫作用与类似于5-HT综合征所见的行为体征的出现有关。目前的数据进一步证明5-HT在光敏性癫痫中起重要作用，并表明5-MeODMT对光敏性的抑制作用源于其对5-HT1受体的激动作用。
