Carlson H, Ronne-Engström E, Ungerstedt U, Hillered L
Department of Neurosurgery, University Hospital of Uppsala, Sweden.
Neurosci Lett. 1992 Jun 8;140(1):30-2. doi: 10.1016/0304-3940(92)90674-v.
Intracerebral microdialysis combined with electrocorticographic recordings was used in a patient subjected to epilepsy surgery. The patient developed a series of partial seizures during an 8 min period. Marked elevations of aspartate (79-fold), glycine (21-fold), glutamate (16-fold) and serine (8-fold) dialysate concentrations occurred in association with onset of the period with seizures. Recurrent seizures occurred, in spite of normalizing amino acid levels. Other amino acids analyzed (aspargine, threonine, arginine, alanine, taurine, tyrosine, phenylalanine, isoleucine and leucine) showed less pronounced changes (1-5 times the basal levels).
对一名接受癫痫手术的患者采用了脑内微透析结合皮质脑电图记录的方法。该患者在8分钟内出现了一系列部分性癫痫发作。在癫痫发作期开始时，透析液中天冬氨酸（升高79倍）、甘氨酸（升高21倍）、谷氨酸（升高16倍）和丝氨酸（升高8倍）的浓度显著升高。尽管氨基酸水平恢复正常，但仍出现了复发性癫痫发作。所分析的其他氨基酸（天冬酰胺、苏氨酸、精氨酸、丙氨酸、牛磺酸、酪氨酸、苯丙氨酸、异亮氨酸和亮氨酸）变化不太明显（为基础水平的1 - 5倍）。
