神经突生长因子受体（NOFR）参与小脑神经发生。
Involvement of a receptor for neurite outgrowth factor (NOFR) in cerebellar neurogenesis.
作者信息
Kato S, Taniura H, Taira E, Miki N
机构信息
Department of Pharmacology, Osaka University School of Medicine, Japan.
出版信息
Neurosci Lett. 1992 Jun 8;140(1):78-80. doi: 10.1016/0304-3940(92)90686-2.
A receptor for neurite outgrowth factor (82 kDa membrane protein, NOFR) was detected in the developing chick cerebellum by immuno- and ligand blots. In immunohistochemical study, NOFR was maximally expressed in the external granular layer of cerebellum at embryonic day 10-12 and gradually decreased until embryonic day 18. Neurite outgrowth and cell migration induced by NOF from cerebellar explants were completely suppressed by the addition of anti-NOFR IgG. These results suggest that NOFR plays an important role in the cerebellar neurogenesis.
通过免疫印迹和配体印迹法在发育中的鸡小脑内检测到一种神经突生长因子受体（82 kDa膜蛋白，NOFR）。在免疫组织化学研究中，NOFR在胚胎第10至12天的小脑外颗粒层中表达最高，并在胚胎第18天前逐渐降低。添加抗NOFR IgG可完全抑制小脑外植体中由NOF诱导的神经突生长和细胞迁移。这些结果表明，NOFR在小脑神经发生中起重要作用。
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