Greif K F, Flaherty K N
Department of Biology, Bryn Mawr College, PA 19010.
Neurosci Lett. 1992 Aug 3;142(1):22-6. doi: 10.1016/0304-3940(92)90611-a.
Previous studies have shown that deafferentation of the rat superior cervical ganglion (SCG) alters the levels of p65 (synaptotagmin), a synaptic vesicle integral membrane protein, within the ganglion. Neonatal deafferentation blocks normal postnatal increases in p65, while deafferentation in adult animals produces a transient increase in p65 expression. The present study examines the time course of the shift from the neonatal to adult pattern of response to deafferentation. Neonatal and 7 day old rats showed the neonatal response to deafferentation. Ganglia from rats aged 14 days or older at deafferentation exhibited the transient increase in p65 at 7 days after surgery. The shift from the neonatal to adult response occurs during the second postnatal week. The change in response to deafferentation may be associated with refinement of synaptic function in a manner yet to be determined.
先前的研究表明，大鼠颈上神经节（SCG）的传入神经切断会改变神经节内突触小泡整合膜蛋白p65（突触结合蛋白）的水平。新生期传入神经切断会阻断出生后p65的正常增加，而成年动物的传入神经切断会使p65表达产生短暂增加。本研究考察了从新生期到成年期对传入神经切断反应模式转变的时间进程。新生大鼠和7日龄大鼠表现出对传入神经切断的新生期反应。在传入神经切断时14日龄或更大年龄大鼠的神经节在手术后7天表现出p65的短暂增加。从新生期反应到成年期反应的转变发生在出生后的第二周。对传入神经切断反应的变化可能与突触功能的精细化有关，其方式尚待确定。
