Greif K F
Department of Biology, Bryn Mawr College, PA 19010.
Neurosci Lett. 1987 Dec 16;83(1-2):133-7. doi: 10.1016/0304-3940(87)90229-1.
Previous studies have shown that deafferentation of the adult rat superior cervical ganglion results in a transient increase in levels of a 65 kDa synaptic vesicle membrane protein (SV). The present study indicates that the observed increase in SV after deafferentation is the result of new protein synthesis. Treatment with cycloheximide, a protein synthesis inhibitor, for 8 h at selected times after surgery produces decreases in SV which are greater than that observed after treatment of unoperated animals. The results suggest that an increased rate of synthesis of this protein is induced by deafferentation. Transsynaptic factors may play important roles in regulation of protein synthesis in sympathetic ganglia.
先前的研究表明，成年大鼠颈上神经节去传入后，一种65 kDa突触小泡膜蛋白（SV）的水平会出现短暂升高。本研究表明，去传入后观察到的SV增加是新蛋白质合成的结果。在手术后选定时间用蛋白质合成抑制剂环己酰亚胺处理8小时，会导致SV减少，且减少幅度大于未手术动物经处理后的减少幅度。结果表明，去传入会诱导这种蛋白质合成速率增加。跨突触因子可能在交感神经节蛋白质合成的调节中起重要作用。
