Salerno M, Huss K, Huss R W
Catholic University of America, Washington, D.C.
Nurse Pract. 1992 Oct;17(10):53-6, 61, 65. doi: 10.1097/00006205-199210000-00014.
House-dust-mite allergen is one of the primary causes of asthma. In many instances, asthma is an immunoglobulin gamma E mediated atopy (i.e., allergen-specific hypersensitivity) that leads to non-specific bronchial hyper-reactivity and subsequent symptom manifestations. These symptoms may range from an annoying cough to full-blown respiratory failure. Allergen-avoidance measures should be a primary mode of treatment for atopic asthmatics. This article focuses on the dust-mite allergen and its relationship to asthma. It details specific avoidance measures that should be implemented by the majority of asthmatics. Studies are cited that support the aggressive use of these measures to decrease allergen exposure, and to subsequently prevent or significantly reduce asthma symptoms. When health care providers have a better understanding of avoidance measures and the rationale underlying their use, these measures are more likely to be valued and given greater emphasis in education and treatment plans. Renewed emphasis on an immunomodulatory approach to asthma treatment may help to reverse the rise in asthma morbidity and mortality rates.
屋尘螨过敏原是哮喘的主要病因之一。在许多情况下，哮喘是一种由免疫球蛋白γE介导的特应性疾病（即过敏原特异性超敏反应），可导致非特异性支气管高反应性及随后的症状表现。这些症状可能从烦人的咳嗽到严重的呼吸衰竭不等。避免接触过敏原措施应是特应性哮喘患者的主要治疗方式。本文聚焦于尘螨过敏原及其与哮喘的关系。详细介绍了大多数哮喘患者应采取的具体避免措施。文中引用了一些研究，这些研究支持积极采用这些措施以减少过敏原暴露，并随后预防或显著减轻哮喘症状。当医疗服务提供者更好地理解避免措施及其使用的基本原理时，这些措施在教育和治疗计划中更有可能受到重视并得到更多强调。重新强调哮喘治疗的免疫调节方法可能有助于扭转哮喘发病率和死亡率上升的趋势。
