Wilcox E R
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
Otolaryngol Clin North Am. 1992 Oct;25(5):1011-6.
Mutations of genes common to several tissues or organs can lead to cellular damage, which may result in hearing impairment as part of a syndromic disorder. Mutations of genes that are unique to the organ of Corti would have a high probability of causing nonsyndromic hearing impairment. It is expected that such genes are involved in auditory transduction as well as in maintaining specific hair cell and supporting cell functions in the organ of Corti. Cloning and describing genes involved with nonsyndromic hearing impairment thus require the construction of a guinea pig cDNA library of the organ of Corti.
几个组织或器官共有的基因突变可导致细胞损伤，这可能会导致听力障碍，成为综合征性疾病的一部分。柯蒂氏器特有的基因突变很可能导致非综合征性听力障碍。预计这些基因参与听觉转导以及维持柯蒂氏器中特定毛细胞和支持细胞的功能。因此，克隆和描述与非综合征性听力障碍相关的基因需要构建柯蒂氏器的豚鼠cDNA文库。
