Somers K D, Schechter G L
Eastern Virginia Medical School, Norfolk.
Otolaryngol Clin North Am. 1992 Oct;25(5):1065-71.
Mutations of the ras gene family appear to be an uncommon genetic alteration in SCCHN. A common region of DNA amplification on chromosome 11q13 has been identified in SCCHN. A cluster of proto-oncogenes (int-2, hst-1, bcl-1, prad-1) has been localized to the 11q13 region. Studies are needed to determine the critical genes in 11q13 whose expression drive the amplicon. Mutations of the p53 tumor suppressor gene are the most common genetic alteration in SCCHN. The hope is that dysregulated oncogenes or tumor suppressor genes may be targets for specific therapy.
ras基因家族的突变在头颈部鳞状细胞癌（SCCHN）中似乎是一种不常见的基因改变。在头颈部鳞状细胞癌中已确定11号染色体长臂13区（11q13）存在一个常见的DNA扩增区域。一组原癌基因（int-2、hst-1、bcl-1、prad-1）已定位到11q13区域。需要开展研究以确定11q13区域中那些其表达驱动扩增子的关键基因。p53肿瘤抑制基因的突变是头颈部鳞状细胞癌中最常见的基因改变。人们希望失调的癌基因或肿瘤抑制基因可能成为特异性治疗的靶点。
