Basso Ricci S, Milani F, Gramaglia A, Basso Ricci P, Borsa G
Divisione di Radioterapia, Università di Milano, Italy.
Panminerva Med. 1992 Apr-Jun;34(2):69-76.
A series of 355 extravisceral soft tissue sarcomas is presented with reference to the effectiveness of radiation treatment for each histological type and the problems of radiotherapy and surgical treatment. Liposarcoma was the most radiosensitive soft tissue sarcoma. By utilizing all types of treatment and especially radiosurgery with postoperative radiotherapy, the percentage of disease-free patients after a minimum of 3 years from treatment varied from 27% to 52.9% for the different types of sarcoma. Nevertheless, in most cases the effectiveness of radiotherapy was unpredictable. It was found that doses varying from 52-60 Gy, with 2 Gy for each of 26-30 applications within 6-8 weeks, were sufficient for radical treatments. In relation to unpredictability of radiotherapy results, it was concluded that preoperative was more advisable than postoperative treatment owing to the possibility to prove the effectiveness of radiotherapy. Postoperative treatment is useless in nonradiosensitive cases and might negatively affect surgical modalities.
本文报告了355例内脏外软组织肉瘤，并参考了每种组织学类型的放射治疗效果以及放疗和手术治疗的问题。脂肪肉瘤是对放疗最敏感的软组织肉瘤。通过采用所有类型的治疗方法，尤其是术后放疗的放射外科手术，不同类型肉瘤治疗后至少3年无病患者的比例在27%至52.9%之间。然而，在大多数情况下，放疗效果是不可预测的。发现剂量在52 - 60 Gy之间，在6 - 8周内分26 - 30次每次2 Gy照射，足以进行根治性治疗。鉴于放疗结果的不可预测性，得出结论：由于有可能证明放疗的有效性，术前治疗比术后治疗更可取。在对放疗不敏感的病例中，术后治疗是无用的，并且可能对手术方式产生负面影响。
