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1
ENTEROMEGALY AND CARDIOMEGALY IN CHAGAS DISEASE.恰加斯病中的巨肠症和心脏扩大
Gut. 1963 Dec;4(4):399-405. doi: 10.1136/gut.4.4.399.
2
Chagas disease of the colon and rectum.结肠和直肠的恰加斯病。
Gut. 1969 Dec;10(12):1009-14. doi: 10.1136/gut.10.12.1009.
3
Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis.恰加斯病与恰加斯综合征：美洲锥虫病的病理学
Adv Parasitol. 1968;6:63-116. doi: 10.1016/s0065-308x(08)60472-8.
4
[INCIDENCE OF ENLARGEMENTS ASSOCIATED WITH CHAGAS' CARDIOPATHY].[与恰加斯心肌病相关的心脏扩大发生率]
Rev Inst Med Trop Sao Paulo. 1964 Nov-Dec;6:287-91.
5
[ETIOPATHOGENESIS OF CHAGAS' MEGACOLON. EXPERIMENTAL CONTRIBUTION].[恰加斯巨结肠的病因学。实验性贡献]
Rev Hosp Clin Fac Med Sao Paulo. 1963 Sep-Oct;18:351-60.
6
[Chagas' bronchiectasis (Quantitative studies on the vegetative nervous system of the respiratory tractpreliminary report].[恰加斯病性支气管扩张（呼吸道自主神经系统的定量研究初步报告）]
Z Tropenmed Parasitol. 1959 Nov;10:304-8.
7
[DIGESTIVE MEGAFORMATIONS AND CHAGAS' DISEASE].
Acad Peru Cir. 1964 Sep;17:297-8.
8
Chagas' disease, a possible cause of megaesophagus and megacolon.恰加斯病，一种可能导致巨食管和巨结肠的病因。
Am J Gastroenterol. 1959 Sep;32:311-6.
9
Megaesophagus, megacolon, and Changes' disease in Chile.智利的巨食管症、巨结肠症及“变化”病。
Gastroenterology. 1963 Apr;44:433-7.
10
[Experimental production of "megas" in animals inoculated with Trypanosoma cruzi].[在接种克氏锥虫的动物中“巨症”的实验性产生]
Rev Hosp Clin Fac Med Sao Paulo. 1961 Sep-Oct;16:338-41.

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Fritz Köberle: A Life Dedicated to Medicine.弗里茨·克贝勒：献身医学的一生。
Rev Soc Bras Med Trop. 2025 Mar 31;58:e011002025. doi: 10.1590/0037-8682-0045-2025. eCollection 2025.
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Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside.恰加斯病的心律失常表现：从实验室到临床的观点。
Circ Res. 2024 May 10;134(10):1379-1397. doi: 10.1161/CIRCRESAHA.124.324507. Epub 2024 May 9.
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Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.组织微域水平上克氏锥虫慢性感染灶与肠神经病变的局部关联。
PLoS Pathog. 2021 Aug 23;17(8):e1009864. doi: 10.1371/journal.ppat.1009864. eCollection 2021 Aug.
4
NOD2 receptor is crucial for protecting against the digestive form of Chagas disease.核苷酸结合寡聚化结构域 2 受体对于预防恰加斯病的消化道形式至关重要。
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Absence of Nocturnal Fall in Blood Pressure Detected by Ambulatory Blood Pressure Monitoring in Acute Chagas Disease Patients with Oral Infection.经动态血压监测，急性恰加斯病患者口腔感染时夜间血压无下降。
Arq Bras Cardiol. 2020 Apr;114(4):711-715. doi: 10.36660/abc.20190143. Epub 2020 May 29.
6
Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation.慢性恰加斯病患者的下尿路功能障碍：临床和尿动力学表现。
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Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence.肥大细胞和 5-羟色胺合成调节结肠中的恰加斯病：临床和实验证据。
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Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon.克氏锥虫感染所致恰加斯病巨结肠患者结肠中的肥大细胞与神经相互作用
Parasitol Res. 2018 Apr;117(4):1147-1158. doi: 10.1007/s00436-018-5792-z. Epub 2018 Feb 22.
9
Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Trypanosoma cruzi Infection.肠道神经元损伤、肌内失神经支配和平滑肌表型改变作为恰加斯病巨结肠的发病机制：来自克氏锥虫感染长期小鼠模型的证据
PLoS One. 2016 Apr 5;11(4):e0153038. doi: 10.1371/journal.pone.0153038. eCollection 2016.
10
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans.锥虫病诱发的巨结肠症表明了肠肌间神经元如何调节大鼠和人类患结肠癌的风险。
PLoS Negl Trop Dis. 2015 Apr 17;9(4):e0003744. doi: 10.1371/journal.pntd.0003744. eCollection 2015 Apr.

本文引用的文献

1
The pathogenesis and clinical management of megacolon with emphasis on the fallacy of the term "idiopathic".巨结肠的发病机制与临床管理，重点探讨“特发性”这一术语的谬误
Surgery. 1951 Dec;30(6):1026-48.
2
[Megacolon and mega-esophagus in central Brazil].[巴西中部的巨结肠和巨食管]
Resen Clin Cient. 1950 Nov;19(11):411-23.
3
Hirschsprung's disease.先天性巨结肠症
Lancet. 1951 Feb 10;1(6650):302-9. doi: 10.1016/s0140-6736(51)92290-8.
4
[Experimental Chagas' cardiopathy. (Quantitative studies on the intracardiac nervous system)].
Z Tropenmed Parasitol. 1959 Nov;10:296-303.
5
[Etiopathogenesis of aperistalsis of the esophagus (cardiospasm; megaesophagus, achalasia of the cardia, etc.)].[食管蠕动障碍（贲门痉挛；巨食管、贲门失弛缓症等）的病因发病机制]
Rev Bras Med. 1956 Aug;13(8):577-90.
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[Chagas disease: a disease of the peripheral autonomic nervous system].
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恰加斯病中的巨肠症和心脏扩大

ENTEROMEGALY AND CARDIOMEGALY IN CHAGAS DISEASE.

作者信息

KOEBERLE F

出版信息

Gut. 1963 Dec;4(4):399-405. doi: 10.1136/gut.4.4.399.

DOI:10.1136/gut.4.4.399
PMID:14084752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1413478/
Abstract

Chagas disease due to a trypanosome infection may lead to extensive destruction of ganglion cells in the peripheral autonomic system and may result in gross enlargement of the oesophagus, colon, and heart. From studies on nerve cell counts it is concluded that the number of ganglion cells in the oesophagus must be reduced to less than half to produce functional disturbances in the oesophagus and to one tenth to produce a megaoesophagus. Problems of terminology are discussed.

摘要

由锥虫感染引起的恰加斯病可能导致外周自主神经系统中神经节细胞的广泛破坏，并可能导致食管、结肠和心脏明显肿大。从神经细胞计数研究得出的结论是，食管中神经节细胞的数量必须减少到不到一半才会在食管中产生功能障碍，减少到十分之一才会导致巨食管。文中讨论了术语问题。