WIGHT P A, SILLER W G
Immunology. 1963 Nov;6(6):513-9.
The effects of varying the dose of the constituents of an inoculum known to produce EAE in a reciprocal cross of Brown Leghorn fowls have been studied. Large amounts of the emulsifying agent suppressed the severity of the histological lesions. Fifty mg. of homologous spinal cord and 2 mg. of per bird were found to be the optimum doses necessary to produce consistently severe histological lesions. A standard procedure for inducing EAE for quantitative studies in `B×I' Brown Leghorn fowls was adopted.
在来航鸡的正反交中,研究了改变已知能诱发实验性变态反应性脑脊髓炎(EAE)的接种物成分剂量所产生的影响。大量乳化剂可抑制组织学损伤的严重程度。发现每只鸡50毫克同源脊髓和2毫克是持续产生严重组织学损伤所需的最佳剂量。采用了一种在“B×I”来航鸡中诱导EAE进行定量研究的标准程序。