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[慢性酒精中毒患者肺结核的抗氧化治疗]

[Antioxidant treatment of pulmonary tuberculosis in patients with chronic alcoholism].

作者信息

Burnusus Z I

出版信息

Probl Tuberk. 1992(5-6):28-30.

PMID:1409509
Abstract

Study of the state of the antioxidant system (AOS) and lipid peroxidation (LPO), according to the data on the alpha-tocopherol content, diene conjugates and acid erythrocyte hemolysis in 69 patients suffering from pulmonary tuberculosis concurrent with chronic alcoholism, has revealed significant differences as against the findings related to healthy subjects (36), to those with stage 11 alcoholism (31) and pulmonary tuberculosis patients (51). Favourable changes in the AOS and LPO during complex treatment that includes antioxidant agents were less manifested in patients with combined pathology and appeared at later terms than in tuberculosis patients. The antioxidant therapy of tuberculosis in chronic alcoholics should take a prolonged time, at least 4 months, since the first favourable changes in the AOS and LPO parameters appear after 4 months, while normalization does not set in even after 6 months.

摘要

根据69例合并慢性酒精中毒的肺结核患者的α-生育酚含量、二烯共轭物和酸性红细胞溶血数据,对其抗氧化系统(AOS)状态和脂质过氧化(LPO)进行的研究表明,与健康受试者(36例)、11期酒精中毒患者(31例)和肺结核患者(51例)的研究结果相比,存在显著差异。在包括抗氧化剂的综合治疗过程中,AOS和LPO的有利变化在合并病变的患者中表现较少,且出现时间晚于肺结核患者。慢性酒精中毒患者的肺结核抗氧化治疗应持续较长时间,至少4个月,因为AOS和LPO参数的首次有利变化在4个月后出现,而即使在6个月后也未实现正常化。

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