Petschow D, Würdinger I, Baumann R, Duhm J, Braunitzer G, Bauer C
J Appl Physiol Respir Environ Exerc Physiol. 1977 Feb;42(2):139-43. doi: 10.1152/jappl.1977.42.2.139.
We have measured the partial pressure of O2 at 50% saturation (P50) and the concentration of various phosphate compounds in the erythrocytes of the bar-headed goose and the guanaco to establish the cause of the high blood O2 affinity in animals who normally reside at high altitude. The same data were obtained in the blood of two goose species, that live at sea level, and in human blood. At standard conditions (pH 7.4, PCO2 40 Torr, 37 degrees C), P50 was 29.7 Torr in the blood of the bar-headed goose and was about 10 Torr higher in the goose species living at sea level. Since the concentration of organic phosphates was not markedly different in the erythrocytes of either goose species we conclude that the hemoglobin of the bar-headed goose reacts more weakly with organic phosphates, which can also be inferred from studies on purified hemoglobin solutions. Likewise, the low P50 of guanaco blood in comparison with human blood can be explained by a reduced interaction of 2,3-bisphosphoglycerate of guanaco hemoglobin compared to the human pigment.
我们测量了斑头雁和原驼红细胞中50%饱和度时的氧分压（P50）以及各种磷酸盐化合物的浓度，以确定正常栖息于高海拔地区动物血液中高氧亲和力的原因。我们还获取了两种生活在海平面的鹅的血液以及人类血液的相同数据。在标准条件下（pH 7.4，二氧化碳分压40托，37摄氏度），斑头雁血液中的P50为29.7托，而生活在海平面的鹅的P50约高10托。由于两种鹅的红细胞中有机磷酸盐的浓度没有显著差异，我们得出结论，斑头雁的血红蛋白与有机磷酸盐的反应较弱，这也可以从对纯化血红蛋白溶液的研究中推断出来。同样，与人类血液相比，原驼血液的低P50可以解释为原驼血红蛋白的2,3 - 二磷酸甘油酸与人类血红蛋白相比相互作用减弱。
