Gurtner G H
J Appl Physiol Respir Environ Exerc Physiol. 1977 Mar;42(3):323-6. doi: 10.1152/jappl.1977.42.3.323.
In 1891 Christian Bohr observed that alveolar PCO2 could exceed arterial PCO2 when high levels of CO2 were present in the inspired air. He proposed that CO2 could be secreted by the lung. His hypothesis was dismissed as being due to experimental error; however, recently the same phenomenon was rediscovered using modern techniques. A possible explanation for the phenomenon may involve coupling between diffusion and chemical reaction of H+, HCO3-, and CO2 in the vicinity of a negatively charged capillary wall, causing the PCO2 to be higher near the wall that in the bulk phase of capillary blood. Alveolar PCO2 is related to the PCO2 near the wall rather than the bulk phase PCO2. The Charged Membrane Hypotheses can explain the phenomenon of CO2 secretion not by a cellular mechanism, but a physical chemical disequilibrium within the capillary which is maintained by blood flow through the capillary.
1891年，克里斯蒂安·玻尔观察到，当吸入空气中存在高浓度二氧化碳时，肺泡二氧化碳分压可能超过动脉二氧化碳分压。他提出肺可能会分泌二氧化碳。他的假设被认为是实验误差所致而遭到摒弃；然而，最近利用现代技术重新发现了同样的现象。对这一现象的一种可能解释可能涉及在带负电荷的毛细血管壁附近，H⁺、HCO₃⁻和CO₂的扩散与化学反应之间的耦合，导致壁附近的二氧化碳分压高于毛细血管血液主体相中的二氧化碳分压。肺泡二氧化碳分压与壁附近的二氧化碳分压有关，而非与主体相二氧化碳分压有关。带电膜假说可以解释二氧化碳分泌现象，这不是通过细胞机制，而是通过毛细血管内的物理化学不平衡来实现的，这种不平衡由流经毛细血管的血流维持。
