NEWTON W L
Bull World Health Organ. 1963;29(4):539-44.
Although reports-some of them conflicting-have been published on the development of resistance to molluscicides in species of Oncomelania, little or nothing is known of the potential of pulmonate snails to develop such resistance, in particular to the much-used compound, sodium pentachlorophenate. This paper describes efforts made between 1952 and 1961 to developed increased resistance in two laboratory-reared strains of Australorbis glabratus. Two lines were eventually established from 10 successive generations of survivors of a 24-hour exposure to LD(90) dosages of pure sodium pentachlorophenate. Each line showed an increase of 50% in the 24-hour LD(50) dosage of chemical over that of the parent strain (e.g., from 1.09 p.p.m. to 1.70 p.p.m. for one strain). While this increase seems low in comparison with dosages recommended for application in the field, it does indicate that colonies of A. glabratus with an increased level of resistance to NaPCP can be developed.
虽然关于钉螺对杀螺剂产生抗性的发展已有报道——其中一些报道相互矛盾，但对于肺螺亚纲蜗牛产生这种抗性的潜力，尤其是对常用化合物五氯酚钠的抗性潜力，人们了解甚少。本文描述了1952年至1961年间为使实验室饲养的两种光滑双脐螺品系产生更高抗性所做的努力。从连续10代经24小时暴露于致死剂量（LD90）的纯五氯酚钠后存活下来的个体中，最终建立了两个品系。与亲本品系相比，每个品系对该化学物质的24小时半数致死剂量（LD50）增加了50%（例如，一个品系从1.09 ppm增加到1.70 ppm）。虽然与推荐用于田间应用的剂量相比，这种增加似乎较低，但它确实表明可以培育出对五氯酚钠具有更高抗性水平的光滑双脐螺群体。
