ADAMS J F
J Clin Pathol. 1964 Jan;17(1):31-8. doi: 10.1136/jcp.17.1.31.
The urinary excretion of injected cyanocobalamin was studied in 30 previously untreated vitamin B(12)-deficient patients by measuring the urinary radioactivity after repeated injections of (58)Co vitamin B(12). The dose range used was 54 to 30,000 mug., each patient receiving the same dose at each injection. The results show that there is no constant trend to the excretion of greater or smaller proportions of the amount injected. It is also shown that there is a wide variation in the amounts excreted by each individual and between individual patients and that the capacity of the tissues to retain injected cyanocobalamin is very great, the amounts retained often being greatly in excess of the normal body stores. The excretion of radioactivity after parenteral infections of (58)Co vitamin B(12) was usually complete within 24 hours but exceptions to this were seen. The significance and value of the results is discussed.
通过测量重复注射（58）钴维生素B12后尿中的放射性，对30例先前未经治疗的维生素B12缺乏患者注射氰钴胺后的尿排泄情况进行了研究。使用的剂量范围为54至30,000微克，每次注射时每位患者接受相同剂量。结果表明，注射量中排泄比例较大或较小并无恒定趋势。还表明，每个个体以及个体患者之间的排泄量存在很大差异，并且组织保留注射氰钴胺的能力非常强，保留量常常大大超过正常身体储备。肠胃外注射（58）钴维生素B12后放射性的排泄通常在24小时内完成，但也有例外情况。对结果的意义和价值进行了讨论。
