MCINTOSH H W, SERAGLIA M, UHLEMANN I, KORE R
Can Med Assoc J. 1963 Dec 28;89(26):1332-3.
The administration of acetazolamide was shown to increase the excretion of calcium in both normal persons and in stone formers, while at the same time the urinary excretion of citrate was reduced. Urinary citrate is potentially of importance in chelating calcium and preventing it from precipitating. In view of the chemical similarity between acetazolamide and the sulfonamides it was considered that the latter might produce a similar effect, with potential hazard if administered to a stone former. This was shown not to be the case.
结果显示，给正常人和结石患者服用乙酰唑胺后，二者的钙排泄量均增加，而与此同时，枸橼酸盐的尿排泄量减少。尿中的枸橼酸盐对于螯合钙并防止其沉淀可能具有重要作用。鉴于乙酰唑胺与磺胺类药物在化学结构上有相似性，有人认为后者可能会产生类似的效果，若给结石患者服用则可能存在潜在风险。但事实并非如此。
