Iarova M S, Pribush A G, Fedorova L I, Abidor I G, Petrov A N, Kulikov A V
Radiobiologiia. 1992 Jul-Aug;32(4):560-5.
The radiosensitivity of mouse myeloma and E. coli cells in the presence of Mg2+ and UO2(2+) ions has been investigated. It has been shown that Mg2+ ions (10(-4) M) do not influence the viability of E. coli and mouse myeloma cells. The presence of Mg2+ ions during irradiation reduces the survival rate of E. coli cells, but the addition of Mg2+ ions after irradiation does not influence the radiosensitivity of E. coli cells. Comparison of the results on the influence of Mg2+ ions upon cells and bilayer lipid membranes (BLM) permits us to suppose that Mg2+ ions increase the positive charge of the membranes thus promoting the increase in the number of short-lived radiolysis products which impair membranes and increase cell radiosensitivity. UO2(2+) ions (10(-4) M) increase the radioresistance of E. coli cells which can be associated with the increase in the lateral membrane viscosity, as it was shown in the studies on BLM.
研究了在Mg2+和UO2(2+)离子存在下小鼠骨髓瘤细胞和大肠杆菌细胞的辐射敏感性。结果表明，Mg2+离子（10(-4) M）不影响大肠杆菌和小鼠骨髓瘤细胞的活力。辐照期间Mg2+离子的存在降低了大肠杆菌细胞的存活率，但辐照后添加Mg2+离子不影响大肠杆菌细胞的辐射敏感性。比较Mg2+离子对细胞和双层脂质膜（BLM）影响的结果使我们推测，Mg2+离子增加了膜的正电荷，从而促进了损害膜并增加细胞辐射敏感性的短寿命辐射分解产物数量的增加。UO2(2+)离子（10(-4) M）增加了大肠杆菌细胞的抗辐射性，这可能与膜横向粘度的增加有关，正如在对BLM的研究中所表明的那样。
