哺乳动物组织中胶原蛋白的代谢
METABOLISM OF COLLAGEN IN MAMMALIAN TISSUES.
作者信息
ROBERTSON W V
出版信息
Biophys J. 1964 Jan;4(1 Pt 2):SUPPL93-114. doi: 10.1016/s0006-3495(64)86930-7.
Abstract
The amino acid composition of collagen is described and the status of knowledge about the synthesis of its unique amino acids, hydroxyproline and hydroxylysine, presented. This is followed by a schematic overview of collagen metabolism. Scurvy and lathyrism, the only two abnormalities of collagen metabolism which can now be reasonably elucidated at a molecular level, are then discussed in some detail. The paper concludes by stressing the importance of recognizing the role of histoarchitecture and of interactions of collagen with other compounds when studying collagen or its metabolism in the whole animal.
摘要
本文描述了胶原蛋白的氨基酸组成，并介绍了其独特氨基酸——羟脯氨酸和羟赖氨酸的合成相关知识现状。接下来是胶原蛋白代谢的示意图概述。然后详细讨论了坏血病和山黧豆中毒，这是目前仅有的两种能在分子水平上得到合理阐释的胶原蛋白代谢异常情况。本文最后强调，在研究全动物体内的胶原蛋白或其代谢时，认识组织结构的作用以及胶原蛋白与其他化合物相互作用的重要性。
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