KILHAM L, MARGOLIS G
Science. 1964 Mar 6;143(3610):1047-8. doi: 10.1126/science.143.3610.1047.
Chronic ataxia associated with hypoplasia of the cerebellum was induced by intracerebral inoculation of newborn hamsters with various strains of rat virus. The condition usually became recognizable within 3 weeks of inoculation and remained static as the animals matured. Preliminary studies suggest that hypoplasia is induced by the rat virus acting on the outer germinal layer of the cerebellum at a critical time in its ontogenic development.
通过向新生仓鼠脑内接种各种大鼠病毒株,诱发了与小脑发育不全相关的慢性共济失调。这种情况通常在接种后3周内变得明显,并随着动物成熟而保持稳定。初步研究表明,发育不全是由大鼠病毒在小脑生发外层发育的关键时期作用所致。