Rabanal J M, Amado J A, Quesada A, Solares G, Díaz J, Vázquez A
Departamento de Anestesiología-Reanimación, Hospital Universitario Marqués de Valdecilla, Santander.
Rev Esp Anestesiol Reanim. 1992 Sep-Oct;39(5):306-8.
To determine the thyroid function in organ donors undergoing cerebral death and evaluate the effects that these possible alterations may exert on the early function of renal graft.
Prospective study. Hormonal analysis when: 1) the diagnosis of cerebral death was made and 2) before organ extraction.
Fifteen organ donors with cerebral death. Twenty-nine patients who received the kidneys of these donors.
Neurotraumatologic Unit at the University Hospital Marques de Valdecilla. Referring center.
All donors showed low T3 and T4 values. Values of T4 and IT4L were significantly lower during the second determination (p < 0.05). Eighty percent of donors showed increased T3r values. TSH was low in 73% of cases. Dopamine requirements in donors or the incidence of acute tubular necrosis in recipients were not significantly higher in donors with lowest T3 values.
The hormonal picture observed in the donors of this study is more characteristic of a "ill euthyroid syndrome" than a real hypothyroidism. The low values of T3 in donors is not associated with higher requirements of inotropic agents, nor with a higher incidence of acute tubular necrosis in renal grafts.
确定脑死亡器官捐献者的甲状腺功能，并评估这些可能的改变对肾移植早期功能的影响。
前瞻性研究。在以下两个时间点进行激素分析：1）做出脑死亡诊断时；2）器官摘取前。
15例脑死亡器官捐献者。29例接受这些捐献者肾脏的患者。
马尔克斯·德·瓦尔迪西利亚大学医院神经创伤科。转诊中心。
所有捐献者的T3和T4值均较低。第二次测定时T4和IT4L的值显著降低（p < 0.05）。80%的捐献者T3r值升高。73%的病例促甲状腺激素水平较低。T3值最低的捐献者，其多巴胺需求量或受者急性肾小管坏死的发生率并无显著升高。
本研究中捐献者的激素情况更符合“低甲状腺素病态综合征”，而非真正的甲状腺功能减退。捐献者T3值低与更高的强心剂需求量无关，也与肾移植中急性肾小管坏死的更高发生率无关。
