[静脉注射免疫球蛋白与自身免疫的抗独特型抑制作用]
[Intravenous immunoglobulins and anti-idiotypic suppression of auto-immunity].
作者信息
Jobin D, Kazatchkine M
机构信息
Service d'Immunologie, Hôpital Broussais, Paris.
出版信息
Rev Med Interne. 1992 Mar-Apr;13(2):162-5. doi: 10.1016/s0248-8663(05)82203-9.
PMID:1410893
Abstract
This review summarizes the clinical use of intravenous immunoglobulins (IVIg) in autoimmune diseases and focuses on the mechanisms by which IVIg suppress autoimmune responses. Evidence is presented of a role of IVIg in modulating the regulatory function of the idiotypic network on the expression of the natural and pathological autoimmune repertoires.
摘要
本综述总结了静脉注射免疫球蛋白（IVIg）在自身免疫性疾病中的临床应用，并重点关注IVIg抑制自身免疫反应的机制。文中提供了证据，证明IVIg在调节独特型网络对天然和病理性自身免疫库表达的调节功能中发挥作用。
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