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从人体组织制备的提取物中的一种（或多种）类组胺物质。

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES.

作者信息

KOVACS B A, PELLETIER G, ROSE B

出版信息

Br J Pharmacol Chemother. 1963 Dec;21(3):419-26. doi: 10.1111/j.1476-5381.1963.tb02009.x.

DOI:10.1111/j.1476-5381.1963.tb02009.x
PMID:14110741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703880/
Abstract

A method for the extraction of an antihistamine-like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5-hydroxytryptamine and bradykinin and the Schultz-Dale reaction on the guinea-pig ileum and rat uterus preparations.

摘要

本文描述了一种从人体组织中提取抗组胺样物质的方法。该方法已证实在多种人体组织中均存在这种活性成分，无一例外。该物质在拮抗组胺、5-羟色胺和缓激肽的体外效应以及对豚鼠回肠和大鼠子宫制剂的舒尔茨-戴尔反应方面具有广泛的活性。

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AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES.从人体组织制备的提取物中的一种（或多种）类组胺物质。
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引用本文的文献

1
Inhibition of ulcer formation by urine extracts with antihistamine activity.具有抗组胺活性的尿液提取物对溃疡形成的抑制作用。
Br J Pharmacol Chemother. 1966 May;27(1):205-12. doi: 10.1111/j.1476-5381.1966.tb01655.x.

本文引用的文献

1
[Demonstration of a hitherto unknown antihistaminic agent formed in the body (resistin)].[体内形成的一种迄今未知的抗组胺剂（抵抗素）的证明]
Arch Int Pharmacodyn Ther. 1951 Dec;88(3):253-67.
2
Antihistaminic effect of eosinophil leukocytes.嗜酸性粒细胞的抗组胺作用。
Experientia. 1950;6(9):349-50. doi: 10.1007/BF02152872.
3
The presence in normal human urine of a substance or substances antagonizing histamine, 5-hydroxytryptamine, and acetylcholine (preliminary report).
Can J Biochem Physiol. 1962 Jan;40:147-51.
4
Antihistamine activity in extracts of horse eosinophils.马嗜酸性粒细胞提取物中的抗组胺活性。
Br J Pharmacol Chemother. 1962 Feb;18(1):101-8. doi: 10.1111/j.1476-5381.1962.tb01154.x.
5
Antihistamine activity of extracts prepared from buffy-coat layer of horse blood and from oak gall.从马血的血沉棕黄层和没食子中制备的提取物的抗组胺活性。
J Physiol. 1960 Dec;154(3):461-78. doi: 10.1113/jphysiol.1960.sp006591.
6
Studies with eosinophil leucocytes isolated from the blood of the horse.对从马血液中分离出的嗜酸性白细胞进行的研究。
Br J Haematol. 1960 Jul;6:229-41. doi: 10.1111/j.1365-2141.1960.tb06238.x.
7
The properties of the isolated granules from blood eosinophiles.
Enzymologia. 1953 Apr 15;16(1):1-13.