Ryrfeldt A, Squire R A, Ekman L
AB Astra, Sodertalje, Sweden.
Toxicol Pathol. 1992;20(1):115-7. doi: 10.1177/019262339202000114.
Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls. Based upon reduced body weight gains and survivals, the doses administered were considered to be toxic. It was concluded that the positive findings represented a class effect, and probably involved glucocorticoid receptors.
在饮用水中给予布地奈德、泼尼松龙或曲安奈德长达104周的雄性大鼠，与对照组相比，嗜碱性病灶的发生率略有增加，肝细胞腺瘤/癌合并发生率显著增加。基于体重增加和存活率降低，所给予的剂量被认为是有毒的。得出的结论是，阳性结果代表了一种类效应，可能涉及糖皮质激素受体。
