小鼠免疫球蛋白两种同种抗原的分子和亚分子定位
MOLECULAR AND SUBMOLECULAR LOCALIZATION OF TWO ISOANTIGENS OF MOUSE IMMUNOGLOBULINS.
作者信息
MISHELL R I, FAHEY J L
出版信息
Science. 1964 Mar 27;143(3613):1440-2. doi: 10.1126/science.143.3613.1440.
Abstract
Three related classes of immunoglobulins ( 7S gamma(-), beta(2)A(-), and gamma(1)M(-) globulin) in normal C3H and C3H and C57BL/6 mouse serums were isolated and examined for the isoantigens Iga-1 and Iga-2. The results indicate that the genetic locus determining the Iga-1 and Iga-2 antigens affects only a portion of the normal mouse immunoglobulin population (that is, 7S gamma-globulin) and only the gamma-specific part ("F" piece) of the 7S gamma-globulin molecule.
摘要
从正常C3H、C3H和C57BL/6小鼠血清中分离出三类相关的免疫球蛋白（7Sγ(-)、β2A(-)和γ1M(-)球蛋白），并检测其同种抗原Iga-1和Iga-2。结果表明，决定Iga-1和Iga-2抗原的基因位点仅影响正常小鼠免疫球蛋白群体的一部分（即7Sγ球蛋白），且仅影响7Sγ球蛋白分子的γ特异性部分（“F”片段）。
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