Leong K H, Feng P H
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 1992 Aug;33(4):393-4.
Gout is a common disease in the primary health care setting. Diagnosis of primary gout is definite if urate crystals are present in synovial fluid or tophi. The colchicine therapeutic trial is a useful diagnostic aid but not specific. Secondary gout is associated with myeloproliferative disease. Non-steroidal anti-inflammatory agents or colchicine are the main stays of treatment in acute gouty arthritis. In the inter-critical period, uricosuric agents or allopurinol can be used to control hyperuricaemia. Allopurinol is the treatment of choice in secondary gout. Asymptomatic hyperuricaemia is not an indication for therapy.
痛风是基层医疗环境中的常见疾病。如果在滑液或痛风石中存在尿酸盐结晶,则原发性痛风的诊断明确。秋水仙碱治疗试验是一种有用的诊断辅助手段,但不具有特异性。继发性痛风与骨髓增殖性疾病相关。非甾体类抗炎药或秋水仙碱是急性痛风性关节炎的主要治疗药物。在发作间期,可使用促尿酸排泄药或别嘌醇来控制高尿酸血症。别嘌醇是继发性痛风的首选治疗药物。无症状性高尿酸血症不是治疗指征。