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狒狒(巴氏狒狒)孕期血清脱氢表雄酮和硫酸脱氢表雄酮

Serum dehydroepiandrosterone and dehydroepiandrosterone sulphate in baboon (Papio Papio) pregnancy.

作者信息

Townsley J D, Pepe G J

出版信息

Acta Endocrinol (Copenh). 1977 Jun;85(2):415-21. doi: 10.1530/acta.0.0850415.

Abstract

Dehydroepiandrosterone (D) and dehydroepiandrosterone sulphate (DS) concentrations were determined by radioimmunoassay in peripheral sera of non-pregnant, pregnant (55 days to term) and newborn baboons and in umbilical sera of animals delivered by Caesarean section close to term. D concentrations (mean +/- SD, microng/100 ml, N) in non-pregnany animals (1.61 +/- 1.32, 23) were not different (P greater than 0.05) from those during pregnancy (1.80 +/- 1.21, 101). DS concentrations, expressed as unconjugated D, in non-pregnant (13.5 +/- 6.0, 23) and pregnant (15.1 +/- 7.5, 101) animals were also similar (P greater than 0.05). However, both D (P less than 0.01) and DS (P less than 0.005) levels increased with gestational age such that serum D (2.46 +/- 1.39, 23, P less than 0.05) and DS (18.9 +/- 5.7, 23, P less than 0.001) levels between 150 and 180 days gestation were greater than in non-pregnant animals. These increases may be important since oestrogen production rises rapidly during late gestation and both D and DS can serve as oestrogen precursors. In both non-pregnant (P less than 0.005) and pregnant (P less than 0.001) animals D and DS concentrations (ratio 1:8) were correlated. Cord serum D levels (2.4 +/- 1.4, 5) were not different from those of maternal serum (P greater than 0.05), while cord DS levels (40.3 +/- 14.8) were greater (P less than 0.001) than those of maternal serum. This may reflect rapid equilibration of D but not DS between foetal and maternal circulations. In sera from neonates, D (19.4 +/- 14.6, 8) and DS 567 +/- 570, 8) concentrations were greater (P less than 0.001) than those in maternal serum, indicating marked post-partal changes in clearance or production of both compounds. The high levels of D and DS in cord and newborn wera are compatible with the view that the baboon foetus makes appreciable contributions of oestrogen precurosrs in pregnancy.

摘要

采用放射免疫分析法测定了未孕、怀孕(55天至足月)和新生狒狒外周血清以及足月剖宫产动物脐血清中脱氢表雄酮(D)和硫酸脱氢表雄酮(DS)的浓度。未孕动物(1.61±1.32,23)的D浓度(平均±标准差,μg/100ml,N)与孕期(1.80±1.21,101)无差异(P>0.05)。未孕(13.5±6.0,23)和怀孕(15.1±7.5,101)动物中以未结合D表示的DS浓度也相似(P>0.05)。然而,D(P<0.01)和DS(P<0.005)水平均随孕周增加,使得妊娠150至180天之间的血清D(2.46±1.39,23,P<0.05)和DS(18.9±5.7,23,P<0.001)水平高于未孕动物。这些升高可能很重要,因为妊娠晚期雌激素产生迅速增加,而D和DS均可作为雌激素前体。在未孕(P<0.005)和怀孕(P<0.001)动物中,D和DS浓度(比例为1:8)均呈相关。脐血清D水平(2.4±1.4,5)与母血清无差异(P>0.05),而脐DS水平(40.3±1-4.8)高于母血清(P<0.001)。这可能反映了D在胎儿和母血循环之间能迅速平衡,而DS则不然。在新生儿血清中,D(19.4±14.6,8)和DS(567±570,8)浓度高于母血清(P<0.001),表明这两种化合物在产后清除或产生方面有明显变化。脐血和新生儿中高水平的D和DS与狒狒胎儿在妊娠期间对雌激素前体有显著贡献的观点相符。

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