Townsley J D, Pepe G J
Acta Endocrinol (Copenh). 1977 Jun;85(2):415-21. doi: 10.1530/acta.0.0850415.
Dehydroepiandrosterone (D) and dehydroepiandrosterone sulphate (DS) concentrations were determined by radioimmunoassay in peripheral sera of non-pregnant, pregnant (55 days to term) and newborn baboons and in umbilical sera of animals delivered by Caesarean section close to term. D concentrations (mean +/- SD, microng/100 ml, N) in non-pregnany animals (1.61 +/- 1.32, 23) were not different (P greater than 0.05) from those during pregnancy (1.80 +/- 1.21, 101). DS concentrations, expressed as unconjugated D, in non-pregnant (13.5 +/- 6.0, 23) and pregnant (15.1 +/- 7.5, 101) animals were also similar (P greater than 0.05). However, both D (P less than 0.01) and DS (P less than 0.005) levels increased with gestational age such that serum D (2.46 +/- 1.39, 23, P less than 0.05) and DS (18.9 +/- 5.7, 23, P less than 0.001) levels between 150 and 180 days gestation were greater than in non-pregnant animals. These increases may be important since oestrogen production rises rapidly during late gestation and both D and DS can serve as oestrogen precursors. In both non-pregnant (P less than 0.005) and pregnant (P less than 0.001) animals D and DS concentrations (ratio 1:8) were correlated. Cord serum D levels (2.4 +/- 1.4, 5) were not different from those of maternal serum (P greater than 0.05), while cord DS levels (40.3 +/- 14.8) were greater (P less than 0.001) than those of maternal serum. This may reflect rapid equilibration of D but not DS between foetal and maternal circulations. In sera from neonates, D (19.4 +/- 14.6, 8) and DS 567 +/- 570, 8) concentrations were greater (P less than 0.001) than those in maternal serum, indicating marked post-partal changes in clearance or production of both compounds. The high levels of D and DS in cord and newborn wera are compatible with the view that the baboon foetus makes appreciable contributions of oestrogen precurosrs in pregnancy.
采用放射免疫分析法测定了未孕、怀孕（55天至足月）和新生狒狒外周血清以及足月剖宫产动物脐血清中脱氢表雄酮（D）和硫酸脱氢表雄酮（DS）的浓度。未孕动物（1.61±1.32，23）的D浓度（平均±标准差，μg/100ml，N）与孕期（1.80±1.21，101）无差异（P＞0.05）。未孕（13.5±6.0，23）和怀孕（15.1±7.5，101）动物中以未结合D表示的DS浓度也相似（P＞0.05）。然而，D（P＜0.01）和DS（P＜0.005）水平均随孕周增加，使得妊娠150至180天之间的血清D（2.46±1.39，23，P＜0.05）和DS（18.9±5.7，23，P＜0.001）水平高于未孕动物。这些升高可能很重要，因为妊娠晚期雌激素产生迅速增加，而D和DS均可作为雌激素前体。在未孕（P＜0.005）和怀孕（P＜0.001）动物中，D和DS浓度（比例为1:8）均呈相关。脐血清D水平（2.4±1.4，5）与母血清无差异（P＞0.05），而脐DS水平（40.3±1-4.8）高于母血清（P＜0.001）。这可能反映了D在胎儿和母血循环之间能迅速平衡，而DS则不然。在新生儿血清中，D（19.4±14.6，8）和DS（567±570，8）浓度高于母血清（P＜0.001），表明这两种化合物在产后清除或产生方面有明显变化。脐血和新生儿中高水平的D和DS与狒狒胎儿在妊娠期间对雌激素前体有显著贡献的观点相符。
