母狒狒和胎儿狒狒（狒狒属物种）血液学细胞和生化指标的个体发生

Ontogeny of hematological cell and biochemical profiles in maternal and fetal baboons (Papio species).

作者信息

Schlabritz-Loutsevitch Natalia E, Hubbard Gene B, Jenkins Susan L, Martin Helen C, Snider Cathy S, Frost Patrice A, Leland M Michelle, Havill Lorena M, McDonald Thomas J, Nathanielsz Peter W

机构信息

Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, USA.

出版信息

J Med Primatol. 2005 Aug;34(4):193-200. doi: 10.1111/j.1600-0684.2005.00109.x.

DOI:10.1111/j.1600-0684.2005.00109.x

PMID:16053497

Abstract

The normal ranges of hematological cell profiles and biochemistry are documented in adult non-pregnant, pregnant, juvenile, and neonatal baboons. Despite the extensive use of the baboon as a model for the study of various aspects of pregnancy, there is no data from paired mothers and their fetuses at different stages of gestation. Hematologic and biochemical profile data were obtained from eight non-pregnant female baboons, 37 mothers and 38 fetal baboons at 30 +/- 2, 90 +/- 2, 125 +/- 2, and 175 +/- 2 days of gestation (mean +/- range; dGA; term, 180 dGA). Changes observed in fetal and maternal blood during normal baboon pregnancy were similar to those reported in human pregnancy. The level of alkaline phosphatase was two times higher in fetal blood circulation than that reported in human pregnancy.

摘要

成年未孕、怀孕、幼年和新生狒狒的血液学细胞谱和生物化学的正常范围已有记录。尽管狒狒被广泛用作研究妊娠各个方面的模型，但尚无不同妊娠阶段配对的母狒狒及其胎儿的数据。从8只未孕雌性狒狒、37只母狒狒以及38只处于妊娠30±2、90±2、125±2和175±2天（平均±范围；妊娠天数；足月为180天妊娠天数）的胎儿狒狒中获取了血液学和生物化学谱数据。正常狒狒妊娠期间胎儿和母体血液中观察到的变化与人类妊娠中报道的变化相似。胎儿血液循环中碱性磷酸酶的水平比人类妊娠中报道的水平高两倍。