Seth P K, Husain R, Mushtaq M, Chandra S V
Acta Pharmacol Toxicol (Copenh). 1977 May;40(5):553-60.
Suckling rats were exposed for 15 and 30 days to manganese through the milk of nursing dams receiving 15 mg MnCl2--4H2O/kg/day orally and after which the neurological manifestations of metal poisoning were studied. No significant differences in the growth rate, developmental landmarks and walking movements were observed between the control and manganese-exposed pups. The metal concentration was significantly increased in the brain of manganese-fed pups at 15 days and exhibited a further three-fold increase over the control, at 30 days. The accumulation of the metal in the brain of manganese-exposed nursing dams was comparatively much less. A significant decrease in succinic dehydrogenase, adenosine triphosphatase, adenosine triphosphatase, adenosine deaminase, acetylcholine esterase and an increase in monoamine oxidase activity was observed in the brain of experimental pups and dams. The results suggest that the developing brain may also be susceptible to manganese.
将哺乳期大鼠通过接受口服15毫克二水合氯化锰/千克/天的母鼠乳汁暴露于锰中15天和30天，之后研究金属中毒的神经学表现。在对照组和暴露于锰的幼崽之间，未观察到生长速率、发育里程碑和行走运动方面的显著差异。在15天时，喂食锰的幼崽大脑中的金属浓度显著增加，到30天时，与对照组相比进一步增加了两倍。暴露于锰的哺乳期母鼠大脑中金属的积累相对少得多。在实验幼崽和母鼠的大脑中，观察到琥珀酸脱氢酶、三磷酸腺苷酶、腺苷脱氨酶、乙酰胆碱酯酶显著降低，单胺氧化酶活性增加。结果表明，发育中的大脑也可能易受锰的影响。
