PARRATT J R
Br J Pharmacol Chemother. 1964 Feb;22(1):34-46. doi: 10.1111/j.1476-5381.1964.tb01541.x.
Using a heated thermocouple technique it was shown that the plasma kinins, kallidin (lys-bradykinin) and bradykinin, increased myocardial blood flow, when given either by single injection or by continuous slow infusion, in the rabbit, cat, dog, monkey and chimpanzee. In every experiment systemic arterial blood pressure and myocardial vascular resistance fell by an amount related to the log of the dose of the kinin administered. These effects were seen with quite small doses of bradykinin and kallidin and demonstrate that the myocardial vascular bed is very sensitive to these plasma kinins. In larger doses, bradykinin increased "corrected temperature" -the myocardial temperature change corrected for alterations in blood flow and with heat losses controlled. This response represents a stimulation of metabolic heat production which was not observed with kallidin.
采用加热热电偶技术表明,在兔、猫、狗、猴和黑猩猩身上,无论是单次注射还是持续缓慢输注血浆激肽缓激肽释放酶(赖氨酰缓激肽)和缓激肽,均会增加心肌血流量。在每项实验中,全身动脉血压和心肌血管阻力的下降幅度与所给予激肽剂量的对数相关。使用相当小剂量的缓激肽和缓激肽释放酶就能观察到这些效应,这表明心肌血管床对这些血浆激肽非常敏感。大剂量时,缓激肽会增加“校正温度”——即针对血流变化和热损失进行控制后校正的心肌温度变化。这种反应代表了代谢产热的刺激,而缓激肽释放酶未观察到这种情况。