Ndububa D A, Erhabor G E, Akinola D O
Department of Medicine, Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Trop Gastroenterol. 1992 Apr-Jun;13(2):56-63.
Sixty-eight proved cases of typhoid and paratyphoid fever were reviewed in a retrospective study covering 5 years (1986-1990). Patients within the age range of 10 to 39 years constituted 82.3 per cent of cases and there was equal incidence in both sexes. The mean duration of illness before presentation was 9.67 days. The major clinical features were fever (97%), abdominal tenderness (-9.4%), headache and abdominal pain (70.58%) each). Intestinal perforation was the commonest complication (27.9%) with a male preponderance (M:F-3:1). Perforation occurred after the first week of illness in 73.7 per cent of cases. Fourteen out of the nineteen patients who perforated were not on therapy at the time of perforation and they constituted 80 per cent of those cases of mortality in which perforation played a role. Surgical management of perforation gave better results than conservative management (mortality rates of 16.7% and 40% respectively). Salmonella was sensitive to Chloramphenicol in all the cases where the organism was grown. There were 10 recorded deaths (14.9%) of whom 60 per cent (i. e. 6 patients) presented after two weeks of illness.
在一项涵盖5年（1986 - 1990年）的回顾性研究中，对68例确诊的伤寒和副伤寒病例进行了分析。年龄在10至39岁之间的患者占病例总数的82.3%，男女发病率相同。就诊前的平均病程为9.67天。主要临床特征为发热（97%）、腹部压痛（94%）、头痛和腹痛（各70.58%）。肠穿孔是最常见的并发症（27.9%），男性居多（男:女 = 3:1）。73.7%的病例在发病第一周后发生穿孔。19例发生穿孔的患者中有14例在穿孔时未接受治疗，在穿孔起作用的死亡病例中，他们占80%。穿孔的手术治疗效果优于保守治疗（死亡率分别为16.7%和40%）。在所有培养出该病菌的病例中，沙门氏菌对氯霉素敏感。记录在案的死亡病例有10例（14.9%），其中60%（即6例患者）在发病两周后就诊。
