BOURSNELL J C
Immunology. 1964 Mar;7(2):127-41.
Specific interchange takes place between I-marked antibody combined with cellular antigens and the free unmarked antiserum antibody in three systems studied: (A) bovine cells with (i) human infectious mononucleosis serum and (ii) rabbit anti-bovine serum and (B) human Rh D-positive cells with Rh incomplete anti-D serum. The rate of interchange is much slower than the initial combination of an unmarked antibody with an unoccupied antigenic site, and also is slower in the Rh incomplete system than in the other systems studied. Rabbit antibovine red cell antiserum partly interchanges with I-marked infectious antibody on bovine cells, but the reverse interaction does not apparently take place at all. Possible reasons are put forward to explain this. The infectious mononucleosis interchange reaction has a large temperature coefficient (about 4.9) which corresponds to a heat of reaction of 29,000 cal.
在所研究的三个系统中,与细胞抗原结合的I标记抗体和游离的未标记抗血清抗体之间发生了特异性交换:(A)牛细胞与(i)人类传染性单核细胞增多症血清以及(ii)兔抗牛血清,以及(B)人类Rh D阳性细胞与Rh不完全抗-D血清。交换速率比未标记抗体与未占据抗原位点的初始结合要慢得多,并且在Rh不完全系统中比在所研究的其他系统中也要慢。兔抗牛红细胞抗血清与牛细胞上的I标记传染性抗体部分发生交换,但反向相互作用显然根本不会发生。文中提出了可能的原因来解释这一现象。传染性单核细胞增多症的交换反应具有较大的温度系数(约4.9),这相当于29,000卡的反应热。