1,1,3-三氰基-2-氨基-1-丙烯刺激双翅目唾液腺体外RNA的合成

SYNTHESIS OF RNA IN VITRO STIMULATED IN DIPTERAN SALIVARY GLANDS BY 1,1,3-TRICYANO-2-AMINO-1-PROPENE.

作者信息

JACOB J, SIRLIN J L

出版信息

Science. 1964 May 22;144(3621):1011-2. doi: 10.1126/science.144.3621.1011.

DOI:10.1126/science.144.3621.1011

Abstract

1,1,3-Tricyano-2-amino-1-propene stimulates by more than one order of magnitude the incorporation in vitro of uridine into the RNA of dipteran salivary glands. The inhibition by actinomycin D is blocked. Higher doses cause a complete inhibition from which a proportion of the glands recover rapidly upon withdrawal of the substance.

摘要

1,1,3-三氰基-2-氨基-1-丙烯能使体外尿苷掺入双翅目唾液腺RNA的量增加一个多数量级以上。放线菌素D的抑制作用被阻断。更高剂量会导致完全抑制，在撤去该物质后，一部分腺体能迅速恢复。