存在抑制剂时双翅目唾液腺中的核仁4s核糖核酸
Nucleolar 4s ribonucleic acid in dipteran salivary glands in the presence of inhibitor.
作者信息
Sirlin J L, Loening U E
出版信息
Biochem J. 1968 Sep;109(3):375-87. doi: 10.1042/bj1090375.
Abstract
- Salivary glands of insect larvae accumulate newly made transfer RNA in the nucleolus when maintained in the presence of nucleoside antagonists that inhibit RNA synthesis preferentially at the chromosome. 2. The nucleus contains precursor transfer RNA, which, on the basis of the general evidence, may originate in the chromosome and then be methylated in the nucleolus. 3. The maturation of precursor ribosomal RNA is blocked in the nucleolus during inhibition. 4. The transport of nuclear RNA to cytoplasm is also blocked. 5. It is suggested that, if the transfer RNA accumulated in the nucleolus does indeed originate in the chromosome, the accumulation may result from the blockage of an obligatory transient association of the RNA with the nucleolus.
摘要
- 当昆虫幼虫的唾液腺在存在优先抑制染色体处RNA合成的核苷拮抗剂的情况下维持时，新合成的转运RNA会在核仁中积累。2. 细胞核含有前体转运RNA，根据一般证据，其可能起源于染色体，然后在核仁中甲基化。3. 在抑制过程中，前体核糖体RNA的成熟在核仁中受阻。4. 核RNA向细胞质的转运也受阻。5. 有人提出，如果在核仁中积累的转运RNA确实起源于染色体，那么这种积累可能是由于RNA与核仁的一种必需的短暂结合受阻所致。
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